abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQAGDALTLSCAASGRSVD	1 - 27	27
CDR-H1	NYAMG	28 - 32	5
HFR2	WFRQAPGKELEFVA	33 - 46	14
CDR-H2	AISWWSGSRTEYADSVKG	47 - 64	18
HFR3	RFTISRDNANGMVYLRMSSLRPEDTAVYYCAA	65 - 96	32
CDR-H3	ERGTYFAGRSQDEYDD	97 - 112	16
HFR4	WGRGTQVT	113 - 120	8
			120

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQAGDALTLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQAGDALTLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQAGDALTLSCAASGRSVD	1 - 27	27
	Contact	LQESGGGLVQAGDALTLSCAASGRSV-	1 - 26	26
	IMGT	LQESGGGLVQAGDALTLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GRSVDNY---	23 - 29	7
	AbM	GRSVDNYAMG	23 - 32	10
	Kabat	-----NYAMG	28 - 32	5
	Contact	----DNYAMG	27 - 32	6
	IMGT	GRSVDNYA--	23 - 30	8
HFR2	Chothia	AMGWFRQAPGKELEFVAAI	30 - 48	19
	AbM	---WFRQAPGKELEFVA--	33 - 46	14
	Kabat	---WFRQAPGKELEFVA--	33 - 46	14
	Contact	---WFRQAPGKELE-----	33 - 43	11
	IMGT	-MGWFRQAPGKELEFVAA-	31 - 47	17
CDR-H2	Chothia	-----SWWSGSR---------	49 - 55	7
	AbM	---AISWWSGSRTE-------	47 - 57	11
	Kabat	---AISWWSGSRTEYADSVKG	47 - 64	18
	Contact	FVAAISWWSGSRTE-------	44 - 57	14
	IMGT	----ISWWSGSRT--------	48 - 56	9
HFR3	Chothia	TEYADSVKGRFTISRDNANGMVYLRMSSLRPEDTAVYYCAA	56 - 96	41
	AbM	--YADSVKGRFTISRDNANGMVYLRMSSLRPEDTAVYYCAA	58 - 96	39
	Kabat	---------RFTISRDNANGMVYLRMSSLRPEDTAVYYCAA	65 - 96	32
	Contact	--YADSVKGRFTISRDNANGMVYLRMSSLRPEDTAVYYC--	58 - 94	37
	IMGT	-EYADSVKGRFTISRDNANGMVYLRMSSLRPEDTAVYYC--	57 - 94	38
CDR-H3	Chothia	--ERGTYFAGRSQDEYDD	97 - 112	16
	AbM	--ERGTYFAGRSQDEYDD	97 - 112	16
	Kabat	--ERGTYFAGRSQDEYDD	97 - 112	16
	Contact	AAERGTYFAGRSQDEYD-	95 - 111	17
	IMGT	AAERGTYFAGRSQDEYDD	95 - 112	18
HFR4	Chothia	-WGRGTQVT	113 - 120	8
	AbM	-WGRGTQVT	113 - 120	8
	Kabat	-WGRGTQVT	113 - 120	8
	Contact	DWGRGTQVT	112 - 120	9
	IMGT	-WGRGTQVT	113 - 120	8

Accession & Annotations

Accession	CAJ55287.1
Source	abYsis-EMBL-IG AM180293 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M206
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	abYsis-EMBL-IG: CAH18860.1
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQAGDALTLSCAASGRSVDNYAMGWFRQAPGKELEFVAAISWWSGSRTEYAD
SVKGRFTISRDNANGMVYLRMSSLRPEDTAVYYCAAERGTYFAGRSQDEYDDWGRGTQVT

DNA Sequence:

ctgcaggagtcagggggaggattggtgcaggctggggacgctctgacactctcctgtgca
gcctctggacgctcggtcgataactatgccatgggctggttccgccaggctccagggaag
gagctcgagtttgtagcggctattagctggtggagtggtagtaggacagagtatgcagac
tccgtgaagggccgattcaccatctccagagacaacgccaacggcatggtgtatttgcga
atgagcagcctccgacctgaggacacggccgtttattactgtgcagctgagcgtggtact
tacttcgccgggagatcccaagatgagtatgacgactggggccgggggacccaagtcacc

Data Source:

Alignment settings:

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