abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLVESGGGLVQPGGSLRLSCAASRSIIS	1 - 30	30
CDR-H1	NNAMG	31 - 35	5
HFR2	WYRQAPGKQRELVA	36 - 49	14
CDR-H2	RISSGGRTTYADSVKG	50 - 65	16
HFR3	RFTISRDNAKTTVYLQMNSLKPEDTAVYYCNA	66 - 97	32
CDR-H3	ASLVRGPLDH	98 - 107	10
HFR4	WGQGTQVTVSS	108 - 118	11
			118

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLVESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	AbM	EVQLVESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	Kabat	EVQLVESGGGLVQPGGSLRLSCAASRSIIS	1 - 30	30
	Contact	EVQLVESGGGLVQPGGSLRLSCAASRSII-	1 - 29	29
	IMGT	EVQLVESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	RSIISNN---	26 - 32	7
	AbM	RSIISNNAMG	26 - 35	10
	Kabat	-----NNAMG	31 - 35	5
	Contact	----SNNAMG	30 - 35	6
	IMGT	RSIISNNA--	26 - 33	8
HFR2	Chothia	AMGWYRQAPGKQRELVARI	33 - 51	19
	AbM	---WYRQAPGKQRELVA--	36 - 49	14
	Kabat	---WYRQAPGKQRELVA--	36 - 49	14
	Contact	---WYRQAPGKQRE-----	36 - 46	11
	IMGT	-MGWYRQAPGKQRELVAR-	34 - 50	17
CDR-H2	Chothia	-----SSGGR---------	52 - 56	5
	AbM	---RISSGGRTT-------	50 - 58	9
	Kabat	---RISSGGRTTYADSVKG	50 - 65	16
	Contact	LVARISSGGRTT-------	47 - 58	12
	IMGT	----ISSGGRT--------	51 - 57	7
HFR3	Chothia	TTYADSVKGRFTISRDNAKTTVYLQMNSLKPEDTAVYYCNA	57 - 97	41
	AbM	--YADSVKGRFTISRDNAKTTVYLQMNSLKPEDTAVYYCNA	59 - 97	39
	Kabat	---------RFTISRDNAKTTVYLQMNSLKPEDTAVYYCNA	66 - 97	32
	Contact	--YADSVKGRFTISRDNAKTTVYLQMNSLKPEDTAVYYC--	59 - 95	37
	IMGT	-TYADSVKGRFTISRDNAKTTVYLQMNSLKPEDTAVYYC--	58 - 95	38
CDR-H3	Chothia	--ASLVRGPLDH	98 - 107	10
	AbM	--ASLVRGPLDH	98 - 107	10
	Kabat	--ASLVRGPLDH	98 - 107	10
	Contact	NAASLVRGPLD-	96 - 106	11
	IMGT	NAASLVRGPLDH	96 - 107	12
HFR4	Chothia	-WGQGTQVTVSS	108 - 118	11
	AbM	-WGQGTQVTVSS	108 - 118	11
	Kabat	-WGQGTQVTVSS	108 - 118	11
	Contact	HWGQGTQVTVSS	107 - 118	12
	IMGT	-WGQGTQVTVSS	108 - 118	11

Accession & Annotations

Accession	AGT78116.1
Source	abYsis-EMBL-IG KF013131 Submitted 26-AUG-2013 Updated 26-AUG-2013
Name	immunoglobulin heavy chain variable region
Clone	VHH G7
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 4b41_A 4b41_B
References	Dorresteijn B., De Kimpe L., Rotman M., Schasfoort R.M.B., Scheper W., van der Maarel S.M., van der Weerd L., Verrips C.T., el Khattabi M. Submitted (06-MAY-2013) to the INSDC. Biology, Utrecht University, Padualaan 8, Utrecht 3584 CH, The Netherlands Dorresteijn B., De Kimpe L., Rotman M., Schasfoort R.M.B., Scheper W., van der Maarel S.M., van der Weerd L., Verrips C.T., el Khattabi M. 'Llama single domain antibodies characterization reveals an amyloid-beta aggregation and toxicity inhibiting antibody' Unpublished.

Tools

Sequences

Amino Acid Sequence:

EVQLVESGGGLVQPGGSLRLSCAASRSIISNNAMGWYRQAPGKQRELVARISSGGRTTYA
DSVKGRFTISRDNAKTTVYLQMNSLKPEDTAVYYCNAASLVRGPLDHWGQGTQVTVSS

DNA Sequence:

gaggtgcagctggtggagtctgggggaggcttggtgcagcctggggggtctctgagactc
tcctgtgcagcctctagaagcatcatcagtaacaatgccatgggctggtaccgccaggct
ccagggaagcagcgcgagttggtcgcacgtattagtagtggtggccgcacaacgtatgca
gactctgtcaagggccgattcaccatctccagagacaacgccaagacaacggtctatctg
caaatgaatagcctgaaacctgaggacacggccgtctattattgcaatgctgcctcgctg
gtccgggggccgttggaccactggggccaggggacccaggtcaccgtctcctca

Data Source:

Alignment settings:

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