abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLVESGGGLVQPGGSLRLSCAASRSIIS	1 - 30	30
CDR-H1	NNAMG	31 - 35	5
HFR2	WYRQAPGKQRELVA	36 - 49	14
CDR-H2	RISSGGRTTYADSVKG	50 - 65	16
HFR3	RFTISRDNAKTTVYLQMNSLKPEDTAVYYCNA	66 - 97	32
CDR-H3	ASLVRGPLDH	98 - 107	10
HFR4	WGQGTQVTVSS	108 - 118	11
			118

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLVESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	AbM	EVQLVESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	Kabat	EVQLVESGGGLVQPGGSLRLSCAASRSIIS	1 - 30	30
	Contact	EVQLVESGGGLVQPGGSLRLSCAASRSII-	1 - 29	29
	IMGT	EVQLVESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	RSIISNN---	26 - 32	7
	AbM	RSIISNNAMG	26 - 35	10
	Kabat	-----NNAMG	31 - 35	5
	Contact	----SNNAMG	30 - 35	6
	IMGT	RSIISNNA--	26 - 33	8
HFR2	Chothia	AMGWYRQAPGKQRELVARI	33 - 51	19
	AbM	---WYRQAPGKQRELVA--	36 - 49	14
	Kabat	---WYRQAPGKQRELVA--	36 - 49	14
	Contact	---WYRQAPGKQRE-----	36 - 46	11
	IMGT	-MGWYRQAPGKQRELVAR-	34 - 50	17
CDR-H2	Chothia	-----SSGGR---------	52 - 56	5
	AbM	---RISSGGRTT-------	50 - 58	9
	Kabat	---RISSGGRTTYADSVKG	50 - 65	16
	Contact	LVARISSGGRTT-------	47 - 58	12
	IMGT	----ISSGGRT--------	51 - 57	7
HFR3	Chothia	TTYADSVKGRFTISRDNAKTTVYLQMNSLKPEDTAVYYCNA	57 - 97	41
	AbM	--YADSVKGRFTISRDNAKTTVYLQMNSLKPEDTAVYYCNA	59 - 97	39
	Kabat	---------RFTISRDNAKTTVYLQMNSLKPEDTAVYYCNA	66 - 97	32
	Contact	--YADSVKGRFTISRDNAKTTVYLQMNSLKPEDTAVYYC--	59 - 95	37
	IMGT	-TYADSVKGRFTISRDNAKTTVYLQMNSLKPEDTAVYYC--	58 - 95	38
CDR-H3	Chothia	--ASLVRGPLDH	98 - 107	10
	AbM	--ASLVRGPLDH	98 - 107	10
	Kabat	--ASLVRGPLDH	98 - 107	10
	Contact	NAASLVRGPLD-	96 - 106	11
	IMGT	NAASLVRGPLDH	96 - 107	12
HFR4	Chothia	-WGQGTQVTVSS	108 - 118	11
	AbM	-WGQGTQVTVSS	108 - 118	11
	Kabat	-WGQGTQVTVSS	108 - 118	11
	Contact	HWGQGTQVTVSS	107 - 118	12
	IMGT	-WGQGTQVTVSS	108 - 118	11

Accession & Annotations

Accession	4b41_A
Source	PDB 4b41 Submitted 27-JUL-2012 Updated 07-AUG-2013
Name	CRYSTAL STRUCTURE OF AN AMYLOID-BETA BINDING SINGLE CHAIN ANTIBODY G7
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	abYsis-EMBL-IG: AGT78116.1 PDB: 4b41_B
References	BERINGER X., DORRESTEIJN B., RUTTEN L., WIENK H., EL KHATTABI M., KROON-BATENBURG J., VERRIPS T. 'CRYSTAL STRUCTURE OF AN AMYLOID-BETA BINDING SINGLE CHAIN ANTIBODY G7' TO BE PUBLISHED

Tools

Sequences

Amino Acid Sequence:

EVQLVESGGGLVQPGGSLRLSCAASRSIISNNAMGWYRQAPGKQRELVARISSGGRTTYA
DSVKGRFTISRDNAKTTVYLQMNSLKPEDTAVYYCNAASLVRGPLDHWGQGTQVTVSS