abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLVESGGGLVQAGGSLRLSCAASGRSFS	1 - 30	30
CDR-H1	RDAMG	31 - 35	5
HFR2	WFRQAPGKERDVVA	36 - 49	14
CDR-H2	AINLNGGRTYSADSVKG	50 - 66	17
HFR3	RFTISRDNDKNTVYLQMSNLKPEDTAVYYCAA	67 - 98	32
CDR-H3	REGDVGLVSYKRSSNYPY	99 - 116	18
HFR4	WGQGTQVTVSS	117 - 127	11
			127

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLVESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	AbM	EVQLVESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	Kabat	EVQLVESGGGLVQAGGSLRLSCAASGRSFS	1 - 30	30
	Contact	EVQLVESGGGLVQAGGSLRLSCAASGRSF-	1 - 29	29
	IMGT	EVQLVESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GRSFSRD---	26 - 32	7
	AbM	GRSFSRDAMG	26 - 35	10
	Kabat	-----RDAMG	31 - 35	5
	Contact	----SRDAMG	30 - 35	6
	IMGT	GRSFSRDA--	26 - 33	8
HFR2	Chothia	AMGWFRQAPGKERDVVAAI	33 - 51	19
	AbM	---WFRQAPGKERDVVA--	36 - 49	14
	Kabat	---WFRQAPGKERDVVA--	36 - 49	14
	Contact	---WFRQAPGKERD-----	36 - 46	11
	IMGT	-MGWFRQAPGKERDVVAA-	34 - 50	17
CDR-H2	Chothia	-----NLNGGR---------	52 - 57	6
	AbM	---AINLNGGRTY-------	50 - 59	10
	Kabat	---AINLNGGRTYSADSVKG	50 - 66	17
	Contact	VVAAINLNGGRTY-------	47 - 59	13
	IMGT	----INLNGGRT--------	51 - 58	8
HFR3	Chothia	TYSADSVKGRFTISRDNDKNTVYLQMSNLKPEDTAVYYCAA	58 - 98	41
	AbM	--SADSVKGRFTISRDNDKNTVYLQMSNLKPEDTAVYYCAA	60 - 98	39
	Kabat	---------RFTISRDNDKNTVYLQMSNLKPEDTAVYYCAA	67 - 98	32
	Contact	--SADSVKGRFTISRDNDKNTVYLQMSNLKPEDTAVYYC--	60 - 96	37
	IMGT	-YSADSVKGRFTISRDNDKNTVYLQMSNLKPEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--REGDVGLVSYKRSSNYPY	99 - 116	18
	AbM	--REGDVGLVSYKRSSNYPY	99 - 116	18
	Kabat	--REGDVGLVSYKRSSNYPY	99 - 116	18
	Contact	AAREGDVGLVSYKRSSNYP-	97 - 115	19
	IMGT	AAREGDVGLVSYKRSSNYPY	97 - 116	20
HFR4	Chothia	-WGQGTQVTVSS	117 - 127	11
	AbM	-WGQGTQVTVSS	117 - 127	11
	Kabat	-WGQGTQVTVSS	117 - 127	11
	Contact	YWGQGTQVTVSS	116 - 127	12
	IMGT	-WGQGTQVTVSS	117 - 127	11

Accession & Annotations

Accession	AGT78117.1
Source	abYsis-EMBL-IG KF013132 Submitted 26-AUG-2013 Updated 26-AUG-2013
Name	immunoglobulin heavy chain variable region
Clone	VHH PS2-8
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 4b5e_A 4b5e_B
References	Dorresteijn B., De Kimpe L., Rotman M., Schasfoort R.M.B., Scheper W., van der Maarel S.M., van der Weerd L., Verrips C.T., el Khattabi M. Submitted (06-MAY-2013) to the INSDC. Biology, Utrecht University, Padualaan 8, Utrecht 3584 CH, The Netherlands Dorresteijn B., De Kimpe L., Rotman M., Schasfoort R.M.B., Scheper W., van der Maarel S.M., van der Weerd L., Verrips C.T., el Khattabi M. 'Llama single domain antibodies characterization reveals an amyloid-beta aggregation and toxicity inhibiting antibody' Unpublished.

Tools

Sequences

Amino Acid Sequence:

EVQLVESGGGLVQAGGSLRLSCAASGRSFSRDAMGWFRQAPGKERDVVAAINLNGGRTYS
ADSVKGRFTISRDNDKNTVYLQMSNLKPEDTAVYYCAAREGDVGLVSYKRSSNYPYWGQG
TQVTVSS

DNA Sequence:

gaggtgcagctggtggagtctgggggaggattggtgcaggctgggggctctctgagactc
tcctgtgcagcctctggacgctccttcagtcgcgatgccatgggctggttccgccaggct
ccagggaaggagcgtgacgttgtagcggctattaacttgaatggtgggcgcacatactct
gcagacagcgtgaagggccgattcaccatctccagagacaacgacaagaacacggtgtat
ctgcaaatgagcaacctgaaacctgaggacacggccgtttattactgtgcagcacgggaa
ggggacgttgggctggtgtcatataagcgctcatcgaattatccgtactggggccagggg
acccaggtcaccgtctcctca

Data Source:

Alignment settings:

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