abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLVESGGGLVQAGGSLRLSCAASGRSFS	1 - 30	30
CDR-H1	RDAMG	31 - 35	5
HFR2	WFRQAPGKERDVVA	36 - 49	14
CDR-H2	AINLNGGRTYSADSVKG	50 - 66	17
HFR3	RFTISRDNDKNTVYLQMSNLKPEDTAVYYCAA	67 - 98	32
CDR-H3	REGDVGLVSYKRSSNYPY	99 - 116	18
HFR4	WGQGTQVTVSS	117 - 127	11
			127

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLVESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	AbM	EVQLVESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	Kabat	EVQLVESGGGLVQAGGSLRLSCAASGRSFS	1 - 30	30
	Contact	EVQLVESGGGLVQAGGSLRLSCAASGRSF-	1 - 29	29
	IMGT	EVQLVESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GRSFSRD---	26 - 32	7
	AbM	GRSFSRDAMG	26 - 35	10
	Kabat	-----RDAMG	31 - 35	5
	Contact	----SRDAMG	30 - 35	6
	IMGT	GRSFSRDA--	26 - 33	8
HFR2	Chothia	AMGWFRQAPGKERDVVAAI	33 - 51	19
	AbM	---WFRQAPGKERDVVA--	36 - 49	14
	Kabat	---WFRQAPGKERDVVA--	36 - 49	14
	Contact	---WFRQAPGKERD-----	36 - 46	11
	IMGT	-MGWFRQAPGKERDVVAA-	34 - 50	17
CDR-H2	Chothia	-----NLNGGR---------	52 - 57	6
	AbM	---AINLNGGRTY-------	50 - 59	10
	Kabat	---AINLNGGRTYSADSVKG	50 - 66	17
	Contact	VVAAINLNGGRTY-------	47 - 59	13
	IMGT	----INLNGGRT--------	51 - 58	8
HFR3	Chothia	TYSADSVKGRFTISRDNDKNTVYLQMSNLKPEDTAVYYCAA	58 - 98	41
	AbM	--SADSVKGRFTISRDNDKNTVYLQMSNLKPEDTAVYYCAA	60 - 98	39
	Kabat	---------RFTISRDNDKNTVYLQMSNLKPEDTAVYYCAA	67 - 98	32
	Contact	--SADSVKGRFTISRDNDKNTVYLQMSNLKPEDTAVYYC--	60 - 96	37
	IMGT	-YSADSVKGRFTISRDNDKNTVYLQMSNLKPEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--REGDVGLVSYKRSSNYPY	99 - 116	18
	AbM	--REGDVGLVSYKRSSNYPY	99 - 116	18
	Kabat	--REGDVGLVSYKRSSNYPY	99 - 116	18
	Contact	AAREGDVGLVSYKRSSNYP-	97 - 115	19
	IMGT	AAREGDVGLVSYKRSSNYPY	97 - 116	20
HFR4	Chothia	-WGQGTQVTVSS	117 - 127	11
	AbM	-WGQGTQVTVSS	117 - 127	11
	Kabat	-WGQGTQVTVSS	117 - 127	11
	Contact	YWGQGTQVTVSS	116 - 127	12
	IMGT	-WGQGTQVTVSS	117 - 127	11

Accession & Annotations

Accession	4b5e_B
Source	PDB 4b5e Submitted 03-AUG-2012 Updated 19-APR-2017
Name	CRYSTAL STRUCTURE OF AN AMYLOID-BETA BINDING SINGLE CHAIN ANTIBODY PS2-8
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	abYsis-EMBL-IG: AGT78117.1 PDB: 4b5e_A
References	BERINGER X., DORRESTEIJN B., RUTTEN L., WIENK H., EL KHATTABI M., KROON-BATENBURG J., VERRIPS T. 'AMYLOID-BETA BINDING SINGLE CHAIN ANTIBODY PS2-8' TO BE PUBLISHED

Tools

Sequences

Amino Acid Sequence:

EVQLVESGGGLVQAGGSLRLSCAASGRSFSRDAMGWFRQAPGKERDVVAAINLNGGRTYS
ADSVKGRFTISRDNDKNTVYLQMSNLKPEDTAVYYCAAREGDVGLVSYKRSSNYPYWGQG
TQVTVSS