abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGSVQVGGSLRVACAASGDTFS	1 - 30	30
CDR-H1	GYLAA	31 - 35	5
HFR2	WFRQAPGKGREGVA	36 - 49	14
CDR-H2	AINSKRHTTSYADSVKG	50 - 66	17
HFR3	RFTISKDNADNIMYLEMNSLKPEDTAIYYCAA	67 - 98	32
CDR-H3	ADAIGLAEYWSTPTLSAARYKY	99 - 120	22
HFR4	WGQGTQVTVSS	121 - 131	11
Tail	HHHHHH	131 - 137	6
			137

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGSVQVGGSLRVACAAS-----	1 - 25	25
	AbM	QVQLQESGGGSVQVGGSLRVACAAS-----	1 - 25	25
	Kabat	QVQLQESGGGSVQVGGSLRVACAASGDTFS	1 - 30	30
	Contact	QVQLQESGGGSVQVGGSLRVACAASGDTF-	1 - 29	29
	IMGT	QVQLQESGGGSVQVGGSLRVACAAS-----	1 - 25	25
CDR-H1	Chothia	GDTFSGY---	26 - 32	7
	AbM	GDTFSGYLAA	26 - 35	10
	Kabat	-----GYLAA	31 - 35	5
	Contact	----SGYLAA	30 - 35	6
	IMGT	GDTFSGYL--	26 - 33	8
HFR2	Chothia	LAAWFRQAPGKGREGVAAI	33 - 51	19
	AbM	---WFRQAPGKGREGVA--	36 - 49	14
	Kabat	---WFRQAPGKGREGVA--	36 - 49	14
	Contact	---WFRQAPGKGRE-----	36 - 46	11
	IMGT	-AAWFRQAPGKGREGVAA-	34 - 50	17
CDR-H2	Chothia	-----NSKRHT---------	52 - 57	6
	AbM	---AINSKRHTTS-------	50 - 59	10
	Kabat	---AINSKRHTTSYADSVKG	50 - 66	17
	Contact	GVAAINSKRHTTS-------	47 - 59	13
	IMGT	----INSKRHTT--------	51 - 58	8
HFR3	Chothia	TSYADSVKGRFTISKDNADNIMYLEMNSLKPEDTAIYYCAA	58 - 98	41
	AbM	--YADSVKGRFTISKDNADNIMYLEMNSLKPEDTAIYYCAA	60 - 98	39
	Kabat	---------RFTISKDNADNIMYLEMNSLKPEDTAIYYCAA	67 - 98	32
	Contact	--YADSVKGRFTISKDNADNIMYLEMNSLKPEDTAIYYC--	60 - 96	37
	IMGT	-SYADSVKGRFTISKDNADNIMYLEMNSLKPEDTAIYYC--	59 - 96	38
CDR-H3	Chothia	--ADAIGLAEYWSTPTLSAARYKY	99 - 120	22
	AbM	--ADAIGLAEYWSTPTLSAARYKY	99 - 120	22
	Kabat	--ADAIGLAEYWSTPTLSAARYKY	99 - 120	22
	Contact	AAADAIGLAEYWSTPTLSAARYK-	97 - 119	23
	IMGT	AAADAIGLAEYWSTPTLSAARYKY	97 - 120	24
HFR4	Chothia	-WGQGTQVTVSS	121 - 131	11
	AbM	-WGQGTQVTVSS	121 - 131	11
	Kabat	-WGQGTQVTVSS	121 - 131	11
	Contact	YWGQGTQVTVSS	120 - 131	12
	IMGT	-WGQGTQVTVSS	121 - 131	11

Accession & Annotations

Accession	APT43333.1
Source	abYsis-EMBL-IG KU302675 Submitted 13-JAN-2017 Updated 13-JAN-2017
Name	anti-GFLV immunoglobulin heavy chain variable region
Organism	Camelus dromedarius
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 5foj_A
References	Hemmer C., Orlov I., Ackerer L., Marmonier A., Hleibieh K., Schmitt-Keichinger C., Vigne E., Gersch S., Komar V., Belval L., Berthold F., Monsion B., Bron P., Lemaire O., Lorber B., Sgro J.-Y., Gutierrez C., Muyldermans S., Demangeat G., Klaholz B.P., Ritzenthaler C. Submitted (11-DEC-2015) to the INSDC. Institut de Biologie Moleculaire des Plantes CNRS-UPR 2357, Associee a l'Universite de Strasbourg, 12 rue du General Zimmer, Strasbourg 67084, France Hemmer C., Orlov I., Ackerer L., Marmonier A., Hleibieh K., Schmitt-Keichinger C., Vigne E., Gersch S., Komar V., Belval L., Berthold F., Monsion B., Bron P., Lemaire O., Lorber B., Sgro J.-Y., Gutierrez C., Muyldermans S., Demangeat G., Klaholz B.P., Ritzenthaler C. 'Structural basis of nanobody-mediated plant virus resistance and vector transmission revealed by cryo-EM' Unpublished.

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGSVQVGGSLRVACAASGDTFSGYLAAWFRQAPGKGREGVAAINSKRHTTSY
ADSVKGRFTISKDNADNIMYLEMNSLKPEDTAIYYCAAADAIGLAEYWSTPTLSAARYKY
WGQGTQVTVSSHHHHHH

DNA Sequence:

caggtgcagctgcaggagtctgggggaggctcggtgcaggtcggagggtctctgagagtc
gcctgtgcagcctctggagacaccttcagtggctacttagcggcctggttccgccaggct
ccagggaaggggcgtgagggggtcgcagccattaatagtaagcgtcataccacatcgtac
gccgactccgtgaagggccgattcaccatctccaaggacaacgccgacaatatcatgtat
ctggaaatgaacagcctgaaacctgaggacacggccatctattactgtgcggcggccgac
gccattgggttagctgaatactggtcaactcctaccctttccgccgcgagatataagtac
tggggccaggggacccaggtcaccgtctcctcacaccaccatcaccatcac

Data Source:

Alignment settings:

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