abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGSVQVGGSLRVACAASGDTFS	1 - 30	30
CDR-H1	GYLAA	31 - 35	5
HFR2	WFRQAPGKGREGVA	36 - 49	14
CDR-H2	AINSKRHTTSYADSVKG	50 - 66	17
HFR3	RFTISKDNADNIMYLEMNSLKPEDTAIYYCAA	67 - 98	32
CDR-H3	ADAIGLAEYWSTPTLSAARYKY	99 - 120	22
HFR4	WGQGTQVTVSS	121 - 131	11
Tail	HHHHHH	131 - 137	6
			137

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGSVQVGGSLRVACAAS-----	1 - 25	25
	AbM	QVQLQESGGGSVQVGGSLRVACAAS-----	1 - 25	25
	Kabat	QVQLQESGGGSVQVGGSLRVACAASGDTFS	1 - 30	30
	Contact	QVQLQESGGGSVQVGGSLRVACAASGDTF-	1 - 29	29
	IMGT	QVQLQESGGGSVQVGGSLRVACAAS-----	1 - 25	25
CDR-H1	Chothia	GDTFSGY---	26 - 32	7
	AbM	GDTFSGYLAA	26 - 35	10
	Kabat	-----GYLAA	31 - 35	5
	Contact	----SGYLAA	30 - 35	6
	IMGT	GDTFSGYL--	26 - 33	8
HFR2	Chothia	LAAWFRQAPGKGREGVAAI	33 - 51	19
	AbM	---WFRQAPGKGREGVA--	36 - 49	14
	Kabat	---WFRQAPGKGREGVA--	36 - 49	14
	Contact	---WFRQAPGKGRE-----	36 - 46	11
	IMGT	-AAWFRQAPGKGREGVAA-	34 - 50	17
CDR-H2	Chothia	-----NSKRHT---------	52 - 57	6
	AbM	---AINSKRHTTS-------	50 - 59	10
	Kabat	---AINSKRHTTSYADSVKG	50 - 66	17
	Contact	GVAAINSKRHTTS-------	47 - 59	13
	IMGT	----INSKRHTT--------	51 - 58	8
HFR3	Chothia	TSYADSVKGRFTISKDNADNIMYLEMNSLKPEDTAIYYCAA	58 - 98	41
	AbM	--YADSVKGRFTISKDNADNIMYLEMNSLKPEDTAIYYCAA	60 - 98	39
	Kabat	---------RFTISKDNADNIMYLEMNSLKPEDTAIYYCAA	67 - 98	32
	Contact	--YADSVKGRFTISKDNADNIMYLEMNSLKPEDTAIYYC--	60 - 96	37
	IMGT	-SYADSVKGRFTISKDNADNIMYLEMNSLKPEDTAIYYC--	59 - 96	38
CDR-H3	Chothia	--ADAIGLAEYWSTPTLSAARYKY	99 - 120	22
	AbM	--ADAIGLAEYWSTPTLSAARYKY	99 - 120	22
	Kabat	--ADAIGLAEYWSTPTLSAARYKY	99 - 120	22
	Contact	AAADAIGLAEYWSTPTLSAARYK-	97 - 119	23
	IMGT	AAADAIGLAEYWSTPTLSAARYKY	97 - 120	24
HFR4	Chothia	-WGQGTQVTVSS	121 - 131	11
	AbM	-WGQGTQVTVSS	121 - 131	11
	Kabat	-WGQGTQVTVSS	121 - 131	11
	Contact	YWGQGTQVTVSS	120 - 131	12
	IMGT	-WGQGTQVTVSS	121 - 131	11

Accession & Annotations

Accession	5foj_A
Source	PDB 5foj Submitted 22-NOV-2015 Updated 30-AUG-2017
Name	ELECTRON CRYO-MICROSCOPY OF GRAPEVINE FANLEAF VIRUS COMPLEX WITH NANOBODY
Organism	Camelus dromedarius
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	abYsis-EMBL-IG: APT43333.1
References	HEMMER C., ORLOV I., ACKERER L., MARMONIER A., HLEIBIEH K., SCHMITT-KEICHINGER C., VIGNE E., GERSCH S., KOMAR V., BELVAL L., BERTHOLD F., MONSION B., BRON P., LEMAIRE O., LORBER B., SGRO Y., GUTIERREZ C., MUYLDERMANS S., DEMANGEAT G., KLAHOLZ P., RITZENTHALER C. 'STRUCTURAL BASIS OF NANOBODY-MEDIATED PLANT VIRUS RESISTANCE AND VECTOR TRANSMISSION REVEALED BY CRYO-EM.' TO BE PUBLISHED

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGSVQVGGSLRVACAASGDTFSGYLAAWFRQAPGKGREGVAAINSKRHTTSY
ADSVKGRFTISKDNADNIMYLEMNSLKPEDTAIYYCAAADAIGLAEYWSTPTLSAARYKY
WGQGTQVTVSSHHHHHH