abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQPGGSLRLSCAASGFTFS	1 - 30	30
CDR-H1	NYKMN	31 - 35	5
HFR2	WVRQAPGKGLEWVS	36 - 49	14
CDR-H2	DISQSGASISYTGSVKG	50 - 66	17
HFR3	RFTISRDNAKNTLYLQMNSLKPEDTAVYYCAR	67 - 98	32
CDR-H3	CPAPFTRDCFDVTSTTYAY	99 - 117	19
HFR4	RGQGTQVTVSS	118 - 128	11
Tail	HHHHHHEPEA	128 - 138	10
			138

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGLVQPGGSLRLSCAASGFTFS	1 - 30	30
	Contact	QVQLQESGGGLVQPGGSLRLSCAASGFTF-	1 - 29	29
	IMGT	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GFTFSNY---	26 - 32	7
	AbM	GFTFSNYKMN	26 - 35	10
	Kabat	-----NYKMN	31 - 35	5
	Contact	----SNYKMN	30 - 35	6
	IMGT	GFTFSNYK--	26 - 33	8
HFR2	Chothia	KMNWVRQAPGKGLEWVSDI	33 - 51	19
	AbM	---WVRQAPGKGLEWVS--	36 - 49	14
	Kabat	---WVRQAPGKGLEWVS--	36 - 49	14
	Contact	---WVRQAPGKGLE-----	36 - 46	11
	IMGT	-MNWVRQAPGKGLEWVSD-	34 - 50	17
CDR-H2	Chothia	-----SQSGAS---------	52 - 57	6
	AbM	---DISQSGASIS-------	50 - 59	10
	Kabat	---DISQSGASISYTGSVKG	50 - 66	17
	Contact	WVSDISQSGASIS-------	47 - 59	13
	IMGT	----ISQSGASI--------	51 - 58	8
HFR3	Chothia	ISYTGSVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYCAR	58 - 98	41
	AbM	--YTGSVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYCAR	60 - 98	39
	Kabat	---------RFTISRDNAKNTLYLQMNSLKPEDTAVYYCAR	67 - 98	32
	Contact	--YTGSVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYC--	60 - 96	37
	IMGT	-SYTGSVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--CPAPFTRDCFDVTSTTYAY	99 - 117	19
	AbM	--CPAPFTRDCFDVTSTTYAY	99 - 117	19
	Kabat	--CPAPFTRDCFDVTSTTYAY	99 - 117	19
	Contact	ARCPAPFTRDCFDVTSTTYA-	97 - 116	20
	IMGT	ARCPAPFTRDCFDVTSTTYAY	97 - 117	21
HFR4	Chothia	-RGQGTQVTVSS	118 - 128	11
	AbM	-RGQGTQVTVSS	118 - 128	11
	Kabat	-RGQGTQVTVSS	118 - 128	11
	Contact	YRGQGTQVTVSS	117 - 128	12
	IMGT	-RGQGTQVTVSS	118 - 128	11

Accession & Annotations

Accession	6niy_N
Source	PDB 6niy Submitted 02-JAN-2019 Updated 23-JAN-2019
Name	A HIGH-RESOLUTION CRYO-ELECTRON MICROSCOPY STRUCTURE OF A CALCITONIN RECEPTOR-HETEROTRIMERIC GS PROTEIN COMPLEX
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 3sn6_N 5uz7_N 5vai_N 6b3j_N 6e3y_N
References	DAL MASO E., GLUKHOVA A., ZHU Y., GARCIA-NAFRIA J., TATE G., ATANASIO S., REYNOLDS A., RAMIREZ-APORTELA E., CARAZO -M., HICK A., FURNESS B., HAY L., LIANG -L., MILLER J., CHRISTOPOULOS A., WANG -W., WOOTTEN D., SEXTON M. 'THE MOLECULAR CONTROL OF CALCITONIN RECEPTOR (CTR) SIGNALING' TO BE PUBLISHED

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQPGGSLRLSCAASGFTFSNYKMNWVRQAPGKGLEWVSDISQSGASISY
TGSVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYCARCPAPFTRDCFDVTSTTYAYRGQ
GTQVTVSSHHHHHHEPEA